Progress in continuous flow synthesis of ibuprofen
Ibuprofen is a non-steroidal anti-inflammatory drug widely used in clinical settings for its antipyretic,analgesic,anti-inflammatory,and anti-rheumatic properties.Its ability to manage high fever,provide potent pain relief with a relatively safe profile has made it a staple in the treatment of fever and pain,generating significant market demand.Nevertheless,the conventional batch manufacturing process for ibuprofen is not only inefficient but also generates substantial waste,causing serious pollution.In recent years,emerging continuous flow reaction technology based on the strong mixing effect and efficient heat and mass transfer of materials in microchannels has effectively addressed the aforementimed issues,enhancing production efficiency and reducing costs.This review summarizes the recent research progress in continuous flow reaction technology for the synthesis of ibuprofen.Notably,a mature synthesis process proposed by Snead involves using isobutylbenzene as the starting material and synthesizing ibuprofen sodium salt in just three steps through Friedel-Crafts acylation,1,2-aryl migration,and hydrolysis,achieving a total yield of 72%.Meanwhile,the introduction of new reagents and methods,such as the use of"super bases"and continuous flow synthesis under photocatalytic conditions,presents innovative ideas and approaches for the continuous flow synthesis of ibuprofen.
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维普
