In order to reduce the toxicity of anti-tumor drug Paclitaxel and enhance its curative effect,a new drug dosage form that is pacli-taxel/poly(lactic acid)composite nanofiber film is prepared by electrospinning technology.Modern analytical instruments are used to test the morphology,chemical structure changes,crystal morphology and Dynamic Contact Angle of the composite nanofiber film.The results show that the composite nanofibers have fine diameters and good morphology.The average diameter of nanofiber without drug addition is 593.2±160.4nm,and with the increase of drug mass fraction,the average fiber diameter further decreases and when the drug mass fraction is 15%,the average fiber diameter drops to 392.4±185.4nm.The drug exists in the fiber membrane in an amorphous state,and there is no chemical reaction between the drug and the carrier poly(lactic acid).The composite nanofiber membrane shows water repellent properties,and the drug mass fraction is positively correlated with water repellency of the composite.
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