To grasp the totality and integrity of the basic principles of Marxism is the key to promote the"two combinations"in the new era,and is the prepositive issue of constructing the modern civilization of the Chinese nation.The research on this issue runs through the whole process of the emergence,development and innovation of Marxism,but there are still some problems such as unclear concept,incomplete definition and imprecise application.The totality of the basic principles of Marxism has the characteristics of global,scientific reason,organic,internal recessive and relative subjectivity,while the totality of the basic principles of Marxism has the characteristics of integration,manifestation,relative objectivity and systemization.The cognition and grasp of the connotation and characteristics of totality and wholeness need to be comprehended with the great historical view,the great practice view and the great civilization view.