Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients

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外文摘要：AIM:To evaluate the effect of antiviral agents on intrahepatic HBV DNA in HBeAg-positive chronic hepatitis B patients.METHODS: Seventy-one patients received treatment with lamivudine, interferon alpha (IFN-α2b) or sequential therapy with lamivudine-IFN-α2b for 48 wk. All subjects were followed up for 24 wk. Serum and intrahepatic HBV DNA were measured quantitatively by PCR. HBV genotypes were analyzed by PCR-RFLP.RESULTS: At the end of treatment, the intrahepatic HBV DNA level in 71 patients decreased from a mean of (6.1 ± 1.0) log10 to (4.9 ± 1.4) log10. Further, a larger decrease was seen in the intrahepatic HBV DNA level in patients with HBeAg seroconversion. Intrahepatic HBV DNA level (before and after treatment) was not significantly affected by the patients'HBV genotype, or by the probability of virological flare after treatment.CONCLUSION: Intrahepatic HBV DNA can be effectively lowered by antiviral agents and is a significant marker for monitoring antivirus treatment. Low intrahepatic HBV DNA level may achieve better efficacy of antivirus treatment.

外文关键词：

Intrahepatic HBV DNAHistologyAntiviral therapyHBV genotype

作者：

Hai-Ying Lu、Li-Wei Zhuang、Yan-Yan Yu、Hadad Ivan、Chong-Wen Si、Zheng Zeng、Jun Li、Dong-Ming Hou、Xin-Yue Chen、Zhong-Hou Han、Yong Chen

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作者单位：

Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China

Indiana University School of Medicine, Indianapolis, IN 46202, United States

Beijing You'an Hospital, Beijing 100054, China

Qinhuangdao Third Hospital, Qinhuangdao 066000, Hebei Province, China

Huai'an Infectious Disease Hospital, Huai'an 223300, Jiangsu Province, China

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基金：

Beijing Municipal Science & Technology Commission

项目编号：

H020920020690

出版年：

2007

世界胃肠病学杂志(英文版)

太原消化病研治中心

世界胃肠病学杂志(英文版)

CSTPCDSCI

影响因子：1.001

ISSN：1007-9327

年,卷(期)：2007.13(20)

被引量2
参考文献量1