首页|Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity

Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity

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AIM: To observe the effects of traditional antiinflammatory medicine Lonicerae Flos (LF) on rat reflux esophagitis (RE) induced by pylorus and forestomach ligation compared with the well-known proton antioxidant, α-tocopherol. METHODS: Rat s were pret reated wi th three different dosages of LF (500, 250 and 125 mg/kg) orally, once a day for 14 d before pylorus and forestomach ligation. Nine hours after pylorus and forestomach ligation, changes to the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), myeloperoxidase and glutathione (GSH) levels, and collagen contents (marker of flexibility) were observed on the esophageal and fundic histopathology. The results were compared with an α-tocopherol (once orally, 1 h before operation, 30 mg/kg) treated group in which the effects on RE were already confirmed. RESULTS: Pylorus and forestomach ligations caused marked increases of gross esophageal and gastric mucosa lesion areas, which corresponded with histopathological changes. In addition, increases of esophageal lipid peroxidation, decreases of SOD, CAT, and GSH-free radical scavengers, increases of collagen were observed. However, these pylorus and forestomach ligation induced RE were dose-dependently inhibited by treatment of 500, 250 and 125 mg/kg of LF extract, mediated by antioxidant effects. RE at 250 mg/kg showed similar effects α-tocopherol. CONCLUSION: The results suggest that antioxidant effects of LF could attenuate the severity of RE and prevent the esophageal mucosal damage, and validate its therapeutic use in esophageal reflux disease.

Reflux esophagitisTocopherolLonicerae FlosAntioxidantMyeloperoxidasePylorus and forestomach ligations

Sae-Kwang Ku、Bu-Il Seo、Ji-Ha Park、Gyu-Yeol Park、Young-Bae Seo、Jae-Soo Kim、Hyeung-Sik Lee、Seong-Soo Roh

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Department of Histology and Anatomy,College of Oriental Medicine, Daegu Haany University,Gyeongsan 712-715, South Korea

Department of Herbology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, South Korea

Department of Herbology, College of Oriental Medicine, Daejeon University, Daejeon 300-716, South Korea

Department of Acupuncture & Moxibustion,College of Oriental Medicine, Daegu Haany University,Gyeongsan 712-715, South Korea

Department of Clinical Laboratory Science,College of Health and Therapy, Daegu Haany University,Gyeongsan, 712-715, South Korea

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2009

10.3748/wjg.15.4799

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

CSTPCDCSCDSCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2009.15(38)
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