首页|Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil

Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil

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AIM: To establish whether virulence factor genes vacA and cagA are present in Helicobacter pylori (H. pylori ) retrieved from gastric mucosa and dental plaque in patients with dyspepsia. METHODS: Cumulative dental plaque specimens and gastric biopsies were submitted to histological examination, rapid urease test and polymerase chain reaction (PCR) assays to detect the presence of cagA and vacA polymorphisms. RESULTS: Detection of H. pylori from dental plaque and gastric biopsy samples was greater by PCR compared to histological examination and the rapid urease test. DNA from H. pylori was detected in 96% of gastric mucosa samples and in 72% of dental plaque samples. Sixty-three (89%) of 71 dental plaque samples that were H. pylori -positive also exhibited identical vacA and cagA genotypes in gastric mucosa. The most common genotype was vacAs1bm1 and cagA positive, either in dental plaque or gastric mucosa. These virulent H. pylori isolates were involved in the severity of clinical outcome. CONCLUSION: These pathogenic strains were found simultaneously in dental plaque and gastric mucosa, which suggests that gastric infection is correlated with the presence of H. pylori in the mouth.

Helicobacter pyloriGastric mucosaDental plaquecagAvacA

M(o)nica Baraúna Assump(c)(a)o、Luisa Caricio Martins、Hivana Patricia Melo Barbosa、Katarine Antonia dos Santos Barile、Sintia Silva de Almeida、Paulo Pimentel Assump(c)(a)o、Tereza Cristina de Oliveira Corvelo

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Endoscopy Department, Jo(a)o de Barros Barreto University Hospital, 66073-000, Belém, Pará, Brazil

Immunopathology Laboratory, Nucleus of Tropical Medicine, Federal University of Pará, 66075-000, Belém, Pará, Brazil

Immunogenetics Laboratory, Federal University of Pará, 66075-110, Belém, Pará, Brazil

Surgery Department, Jo(a)o de Barros Barreto University Hospital, 66073-000, Belém, Pará, Brazil

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Supported by Coordena (c)(a) o de Aperfei(c)oamento de Pessoal de Nível Superior and Federal University of Pará

2010

10.3748/wjg.v16.i24.3033

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

CSTPCDCSCDSCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2010.16(24)
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