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Recurrence and rejection in liver transplantation for primary sclerosing cholangitis

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Primary sclerosing cholangitis (PSC) is a chronic progressive inflammatory disease affecting the bile ducts, leading to fibrosis and eventually cirrhosis in most patients. Its etiology is unknown and so far no effective medical therapy is available. Liver transplantation (LTX) is the only curative treatment and at present PSC is the main indication for LTX in the Scandinavian countries. Close to half of the PSC patients experience one or more episodes of acute cellular rejection (ACR) following transplantation and approximately 1/5 of the transplanted patients develop recurrent disease in the graft. In addition, some reports indicate that ACR early after LTX for PSC can influence the risk for recurrent disease. For these important post-transplantation entities affecting PSC patients, we have reviewed the current literature on epidemiology, pathogenesis, treatment and the possible influence of rejection on the risk of recurrent disease in the allograft.

Liver transplantationPrimary sclerosing cholangitisRejectionRecurrence

Bjarte Fosby、Tom H Karlsen、Espen Melum

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Department of Transplantation Surgery, Clinic for Specialized Medicine and Surgery, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway

Norwegian Primary Sclerosing cholangitis Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital, Rikshospitalet,0027 Oslo, Norway

Norwegian Primary Sclerosing cholangitis Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway

Norwegian PrimarySclerosing cholangitis Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital, Rikshospitalet,0027 Oslo, Norway

Research Institute for Internal Medicine, OsloUniversity Hospital, Rikshospitalet, 0027 Oslo, Norway

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2012

10.3748/wjg.v18.i1.1

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(1)
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