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Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test

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AIM: To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay. METHODS: This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration. RESULTS: Using the UBT as the standard, the sensitivity, specificity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were significantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A 450/630) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099). CONCLUSION: The stool antigen test was equally sensitive to the UBT, making it a useful and reliable diagnostic method, even during PPI administration.

Helicobacter pyloriStool antigen testUrea breath testProton pump inhibitor

Masaaki Kodama、Kazunari Murakami、Tadayoshi Okimoto、Yoshihiro Fukuda、Tadashi Shimoyama、Masumi Okuda、Chieko Kato、Intetsu Kobayashi、Toshio Fujioka

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Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu city, Oita 879-5593, Japan

Faculty of Medicine, Hasama Division, Health Science Center, Oita University, Yufu city, Oita 879-5593, Japan

General Medicine and Community Health Science, Hyogo College of Medicine, Hyogo 663-8501, Japan

Department of Gastroenterology, Hirosaki University, Graduate School of Medicine, 5zaifu-cho, Hirosaki 036-8562, Japan

Toyama City Medical Association Health Management Center, Kyodo, Toyama 930-0951, Japan

Department of Microbiology, Toho University, Ota-ku, Tokyo 143-8540, Japan

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2012

10.3748/wjg.v18.i1.44

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(1)
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