首页|Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest

Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest

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AIM: To investigate the growth effects of 4-phenyl butyric acid (PBA) on human gastric carcinoma cells and their mechanisms. METHODS: Moderately-differentiated human gastric carcinoma SGC-7901 and lowly-differentiated MGC-803 cells were treated with 5, 10, 20, 40, and 60 μmol/L PBA for 1-4 d. Cell proliferation was detected using the MTT colorimetric assay. Cell cycle distributions were examined using flow cytometry. RESULTS: The proliferation of gastric carcinoma cells was inhibited by PBA in a dose- and time-dependent fashion. Flow cytometry showed that SGC-7901 cells treated with low concentrations of PBA were arrested at the G0/G1 phase, whereas cells treated with high concentrations of PBA were arrested at the G2/M phase. Although MGC-803 cells treated with low concentrations of PBA were also arrested at the G0/G1 phase, cells treated with high concentrations of PBA were arrested at the S phase. CONCLUSION: The growth inhibitory effect of PBA on gastric cancer cells is associated with alteration of the cell cycle. For moderately-differentiated gastric cancer cells, the cell cycle was arrested at the G0/G1 and G2/M phases. For lowly-differentiated gastric cancer cells, the cell cycle was arrested at the G0/G1 and S phases.

Histone deacetylase inhibitor4-phenyl butyric acidGastric carcinomaAnticancer effectCell cycleMGC-803SGC-7901

Long-Zhu Li、Hong-Xia Deng、Wen-Zhu Lou、Xue-Yan Sun、Meng-Wan Song、Jing Tao、Bing-Xiu Xiao、Jun-Ming Guo

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Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China

宁波自然科学基金Natural Sciences Foundation of ZhejiangCollege Students' Science-Technology Innovation Program of Zhejiang ProvinceExcellent Dissertation Foundation of Ningbo UniversityKC Wong Magna Fund of Ningbo UniversityScientific InnovationTeam Project of Ningbo

2009A610134Y2072442009592010142011B82014

2012

10.3748/wjg.v18.i1.79

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(1)
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