首页|Population-based study of DNA image cytometry as screening method for esophageal cancer

Population-based study of DNA image cytometry as screening method for esophageal cancer

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
AIM: To explore the DNA image cytometry (DNA-ICM) technique as a primary screening method for esophageal squamous precancerous lesions.METHODS: This study was designed as a populationbased screening study. A total of 582 local residents aged 40 years-69 years were recruited from Linzhou in Henan and Feicheng in Shandong. However, only 452 subjects had results of liquid-based cytology, DNA-ICM and pathology. The sensitivity and specificity of DNAICM were calculated and compared with liquid-based cytology in moderate dysplasia or worse. RESULTS: Sensitivities of DNA-ICM ranging from at least 1 to 4 aneuploid cells were 90.91%, 86.36%, 79.55% and 77.27%, respectively, which were better than that of liquid-based cytology (75%). Specificities of DNA-ICM were 70.83%, 84.07%, 92.65% and 96.81%, but the specificity of liquid-based cytology was 91.91%. The sensitivity and specificity of a combination of liquid-based cytology and DNA-ICM were 84.09% and 85.78%, respectively. CONCLUSION: It is possible to use DNA-ICM technique as a primary screening method for esophageal squamous precancerous lesions.

DNA image cytometryAneuploidyScreeningEsophageal cancerPrecancerous lesions

Lin Zhao、Wen-Qiang Wei、De-Li Zhao、Chang-Qing Hao、Dong-Mei Lin、Qin-Jing Pan、Xin-Qing Li、Fu-Hua Lei、Jin-Wu Wang、Guo-Qing Wang、Qi Shang、You-Lin Qiao

展开 >

Department of Cancer Epidemiology,Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Department of Epidemiology, Feicheng People's Hospital, Feicheng 271600, Shandong Province, China

Department of Endoscopy, Linzhou Cancer Hospital, Linzhou 456500, Henan Province, China

Department of Pathology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Department of Pathology, Feicheng People's Hospital,Feicheng 271600, Shandong Province, China

Department of Pathology, Linzhou Cancer Hospital,Linzhou 456500, Henan Province, China

展开 >

Grants from the Ministry of Health of ChinaGrants from Cancer Institute/Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

200902002-82009YF50

2012

10.3748/wjg.v18.i4.375

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(4)
  • 7
  • 29