首页|Chronic fatigue is associated with increased disease-related worries and concerns in inflammatory bowel disease

Chronic fatigue is associated with increased disease-related worries and concerns in inflammatory bowel disease

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AIM: To investigate the impact of chronic fatigue on disease-related worries in inflammatory bowel disease (IBD) and the potential multicolinearity between subjective questionnaires. METHODS: Patients in remission or with mild-tomoderate disease activity completed the fatigue questionnaire (FQ), the rating form of IBD patient concerns (RFIPC), the Short-Form 36 (SF-36), and IBD questionnaire (N-IBDQ). In addition, clinical and epidemiological data were obtained. RESULTS: In total, 140 patients were included; of which 92 were diagnosed with ulcerative colitis and 48 with Crohn's disease. the mean age of patients with chronic fatigue was 44.2 years (SD =15.8) and for non-fatigued patients was 44.7 years (SD = 16.0). Chrnnic fatigued patients had clinically significantly increased levels of disease-related worries, as measured by Cohen's d effect size. Worries about having an ostomy bag, loss of bowel control, and energy levels were most prominent in both chronic fatigued and non-chronic fatigued IBD patients. Variance inflation factor (VIF) and tolerance indicated that there were no problematic multicolinearity among the FQ, RFIPC, SF-36 and N-IBDQ responses (VIF < 5 and tolerance >2). CONCLUSION: Chronic fatigue is associated with increased levels of disease-related worries and concerns in IBD. Increased levels of worries were also associated with impaired health-related quality of life.

FatigueWorriesHealth-related quality of lifePatient reported outcomeInflammatory bowel disease

Lars-Petter Jelsness-Jφrgensen、Tomm Bernklev、Magne Henriksen、Roald Torp、Bjφrn Mourn

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Department of Gastroenterology, Oslo University Hospital Aker and φstfold Hospital Trust, 1603 Fredrikstad, Norway

Department of Research, Telemark Hospital Trust, 3710 Skien, Norway

Department of Gastroenterology, φstfold Hospital Trust, 1603 Fredrikstad, Norway

Department of Gastroenterology, Innlandet Hospital Trust, 2380 Brummundal, Norway

Department of Gastroenterology, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, 0586 Oslo, Norway

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Oslo University Hospital AkerHospital Trust; and Ferring Pharmaceuticals

2012

10.3748/wjg.v18.i5.445

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(5)
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