首页|ABO blood type, diabetes and risk of gastrointestinal cancer in northern China

ABO blood type, diabetes and risk of gastrointestinal cancer in northern China

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
AIM: To explore the potential risk factors related to gastrointestinal cancer in northern China.METHODS: A total of 3314 cases of gastrointestinal cancer (esophageal, gastric, pancreatic and biliary) and 2223 controls (including healthy individuals, glioma and thyroid cancer) were analyzed by case-control study. Multivariable logistic regression analysis was applied to evaluate the association between different cancers and hepatitis B surface antigen, sex, age, blood type, diabetes, or family history of cancer.RESULTS: Type 2 diabetes was significantly associated with gastric, biliary and pancreatic cancer with an OR of 2.0-3.0. Blood type B was significantly associated with esophageal cancer [odd ratio (OR) = 1.53, 95% confidence interval (CI) = 1.10-2.14] and biliary cancer (OR = 1.49, 95% CI = 1.09-2.05). The prevalence of type 2 diabetes was significantly higher in gastric, biliary and pancreatic cancers compared with other groups, with ORs ranging between 2.0 and 3.0. Family history of cancer was strongly associated with gastrointestinal compared with other cancers.CONCLUSION: Blood type B individuals are susceptible to esophageal and biliary cancer. Type 2 diabetes is significantly associated with gastric, biliary and especially pancreatic cancer.

Blood typeType 2 diabetesGastric cancerEsophageal cancerPancreatic cancer

Yan Gong、Yun-Sheng Yang、Xiao-Mei Zhang、Ming Su、Jean Wang、Jin-Dong Han、Ming-Zhou Guo

展开 >

Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China

Chinese Academy of Sciences Key Laboratory of Molecular Developmental Biology, Center for Molecular Systems Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

Department of Medicine (Gastroenterology), Johns Hopkins University, Baltimore, MD 21287, United States

Supported by The National Basic Research Program,973 ProgramSupported by The National Basic Research Program,973 ProgramChina National Science FoundationChina National Science FoundationChina National Science FoundationChinese Academy of Sciences44 Postdoctoral Fund of China

2010CB9128022006CB910700810719533089003330620120433KSCX1-YW-R-4020080441314

2012

10.3748/wjg.v18.i6.563

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(6)
  • 9
  • 30