首页|Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases
Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases
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AIM:To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases.METHODS:Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma.RESULTS:Immunostaining was seen in most cases,and COX-2 expression was higher in lymph node metastases than in corresponding primary gastric tumors of intestinal,diffuse and mixed carcinomas,with a statistically significant difference in the diffuse histotype (P=0.0108).CONCLUSION:COX-2 immunoexpression occurs frequently in primary gastric carcinomas,but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype.
Paulo RC Almeida、Francisco VA Ferreira、Cássio C Santos、Francisco D Rocha-Filho、Raul RP Feitosa、Esther AA Falc(a)o、Belise K Cavada、Roberto CP Lima-Júnior、Ronaldo A Ribeiro
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Faculty of Medicine, Federal University of Ceará,60.430-350 Fortaleza, Brazil
Hospital of Cancer, Cancer Institute of Ceará, 60.430-350 Fortaleza, Brazil
NETL
NSTL
万方数据
维普
