首页|Effects of endoscopic sphincterotomy on biliary epithelium:A case-control study

Effects of endoscopic sphincterotomy on biliary epithelium:A case-control study

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AIM:To study the long-term effects of endoscopic sphincterotomy on biliary epithelium.METHODS:This is a prospective case-control study.A total of 25 patients with a median age of 71 years (range 49-89 years) and prior endoscopic sphincterotomy (ES) for benign disease formed the first group.The median time from ES was 42 mo (range 8-144 mo).Another 25 patients with a median age of 76 years (range 44-94 mo) and similar characteristics who underwent current endoscopic retrograde cholangiopancreatography (ERCP) and ES for benign disease formed the second group (control group).Brush cytology of the biliary tree with p53 immunocytology was performed in all patients of both groups.ERCPs and recruitment were conducted at the Endoscopic Unit of Aretaieion University Hospital and Tzaneio Hospital,Athens,from October 2006 to June 2010.RESULTS:No cases were positive or suspicious for malignancy.Epithelial atypia was higher in the first group (32％ vs 8％ in the second group,P =0.034).Acute cholangitis and previous biliary operation rates were also higher in the first group (acute cholangitis,60％ vs 24％ in the second group,P =0.01; previous biliary operation,76％ vs 24％ in the second group,P =0.001).Subgroup analysis showed that previous ES was the main causal factor for atypia,which was not related to the time interval from the ES (P =0.407).Two patients (8％) with atypia in the first group were p53-positive.CONCLUSION:ES causes biliary epithelial atypia that represents mostly reactive/proliferative rather than premalignant changes.The role of p53 immunoreactivity in biliary atypia needs to be further studied.

Endoscopic sphincterotomyBrush cytologyAtypiaCholangiocarcinomap53 immunocytology

John Kalaitzis、Antonios Vezakis、George Fragulidis、Irene Anagnostopoulou、Spyros Rizos、Efstathios Papalambros、Andreas Polydorou

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First Department of Surgery,Tzaneio General Hospital of Piraeus, 18536 Piraeus, Greece

Second Department of Surgery and Endoscopic Unit, National and Kapodistrian University of Athens Medical School, Aretaieion Hospital, 11527 Athens, Greece

Department of Cytology, Tzaneio General Hospital of Piraeus, 18536 Piraeus, Greece

First Department of Surgery, National and Kapodistrian University of Athens Medical School,Laiko General Hospital, 11527 Athens, Greece

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2012

10.3748/wjg.v18.i8.794

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(8)
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