首页|Amplifications of NCOA3 gene in colorectal cancers in a Chinese population

Amplifications of NCOA3 gene in colorectal cancers in a Chinese population

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AIM:To investigate the copy number variation of NAC03 gene in colorectal cancer (CRC) and its correlation with tumor progression.METHODS:A total of 142 samples of case-matched CRC tissues and adjacent normal tissues were obtained from patients undergoing bowel resection.Quantitative real-time polymerase chain reaction method was used to investigate the copy number variations of NCOA3 as well as gene expression in the collected tissues.RESULTS:Copy number gains of NCOA3 were detected in 39 CRC samples (27.5％) and were correlated with tumor progression (x2 =6.42,P =0.0112).Moreover,there was a positive correlation between copy number gain and mRNA over-expression of NCOA3 in CRCs (P =0.0023).Expression level of NCOA3 mRNA was also enhanced in the CRC samples with unaltered copy numbers (3.85 ± 1.23 vs 2.71 ± 0.64,P ＜ 0.01).CONCLUSION:Sporadic colorectal cancers exhibit different mechanisms of NCOA3 regulation.

Colorectal cancerNCOA3Gene copy numberGene expressionTumor progression

Zhi Li、Zheng-Yu Fang、Yi Ding、Wan-Tong Yao、Yang Yang、Zhong-Qing Zhu、Wen Wang、Qin-xian Zhang

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Department of Histology and Embryology, Basic Medical College of Zhengzhou University,Zhengzhou 450001, Henan Province, China

Department of General Surgery, Henan Province Tumor Hospital, Zhengzhou 450001, Henan Province, China

Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, Shenzhen 518036, Guangdong Province, China

Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China

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Fundamental Research Plan of Shenzhen City

JC201005260215A

2012

10.3748/wjg.v18.i8.855

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(8)
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