首页|Low-dose steroid pretreatment ameliorates the transient impairment of liver regeneration

Low-dose steroid pretreatment ameliorates the transient impairment of liver regeneration

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AIM:To determine if liver regeneration (LR) could be disturbed following radiofrequency (RF) ablation and whether modification of LR by steroid administration occurs.METHOIDS:Sham operation,partial hepatectomy (PH),and partial hepatectomy with radiofrequency ablation (PHA) were performed on adult Fisher 344 rats.We investigated the recovery of liver volume,DNA synthetic activities,serum cytokine/chemokine levels and signal transducers and activators of transcription 3 DNA-binding activities in the nucleus after the operations.Additionally,the effects of steroid (dexamethasone) pretreatment in the PH group (S-PH) and the PHA group (S-PHA) were compared.RESULTS:The LR after PHA was impaired,with high serum cytokine/chemokine induction compared to PH,although the ratio of the residual liver weight to body weight was not significantly different.Steroid pretreatment disturbed LR in the S-PH group.On the other hand,low-dose steroid pretreatment improved LR and suppressed tumor necrosis factor (TNF)-α elevation in the S-PHA group,with recovery of STAT3 DNA-binding activity.On the other hand,low-dose steroid pretreatment improved LR and suppressed TNF-α elevation in the S-PHA group,with recovery of STAT3 DNA-binding activity.CONCLUSION:LR is disturbed after RF ablation,with high serum cytokine/chemokine induction.Low-dose steroid administration can improve LR after RF ablation with TNF-α suppression.

Liver regenerationRadiofrequency ablationSteroidTumor necrosis factorHepatectomy

Toshihito Shibata、Toru Mizuguchi、Yukio Nakamura、Masaki Kawamoto、Makoto Meguro、Shigenori Ota、Koichi Hirata、Hidekazu Ooe、Toshihiro Mitaka

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Department of Surgery Ⅰ, Sapporo Medical University Hospital, Sapporo, Hokkaido 060-8543, Japan

Department of Tissue Development and Regeneration, Molecular Pathophysiology, Frontier Medical Research Institute, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8556, Japan

Grant-in-Aid for Scientific Research from Ministry of Education,Culture,Sports,Science and TechnologyGrant-in-Aid for Scientific Research from Ministry of Education,Culture,Sports,Science and TechnologyGrant-in-Aid for Scientific Research from Ministry of Education,Culture,Sports,Science and TechnologyGrant-in-Aid for Scientific Research from Ministry of Education,Culture,Sports,Science and TechnologyYuasa memorial foundation (to Mizuguchi T)

23791489 to Nakamura Y23591993 to Mizuguchi T21390365 to Mitaka T22390259

2012

10.3748/wjg.v18.i9.905

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(9)
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