首页|Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference

Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference

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AIM:To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan(C) (FS)] as a reference.METHODS:Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined.Sixtyeight patients underwent liver biopsy.RESULTS:Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7％) vs 482/606 (79.5％),P ＜ 0.001].ARFI-SWV correlated significantly with FS-LS (r =0.920,P ＜ 0.001).ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS ＜ 7.6 kPa); 1.46±0.27 m/s for patients with significant liver fibrosis (7.6 ＜ FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS ＞ 13.0 kPa)).ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4％ and specificity 92.6％) and for liver cirrhosis (1.60 m/s; sensitivity 92.3％ and specificity 96.5％).The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0％ and specificity 80.0％) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100％ and specificity 85.7％),for patients who underwent liver biopsy.An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations.CONCLUSION:An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis.

Acoustic radiation force impulse imagingElastographyFibroscanLiver

Gerald Kircheis、Abdurrahman Sagir、Christoph Vogt、Stephan vom Dahl、Ralf Kubitz、Dieter H(a)ussinger

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Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf,Moorenstrasse 5, Düsseldorf40225, Germany

Department of Internal Medicine, St.Josef Hospital Moers, Asberger Str.4, Moers 47441, Germany

Department of Internal Medicine/Gastroenterology, St.Franziskus Hospital, Sch(o)nsteinstraβe 63, K(o)ln 50825, Germany

2012

10.3748/wjg.v18.i10.1077

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(10)
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