Association between gastric cancer and-1993 polymorphism of TBX21 gene

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外文摘要：AIM:To investigate the association between the polymorphism of TBX21 gene and the risk of gastric cancer in a Chinese population.METHODS:The-1993 polymorphism located in TBX21 gene promoter region was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.The risk between TBX21 gene genotype and gastric cancer was determined by multivariate logistic regression analysis in 220 gastric cancer patients and 262 cancer-free controls matched by age,sex and ethnicity.RESULTS:Compared with the TBX21-1993TT genotype,the-1993CC genotype exhibited a significantly elevated risk for gastric cancer [Odds ratio (OR) =3.42,95％ confidence interval (CI):1.41-8.31].The relationship between the-1993 polymorphic genotype and the invasive status such as lymph node and distant metastasis was found among the gastric cancer patients (OR =4.02,95％ CI:1.87-8.66; OR =7.02,95％ CI:3.44-14.34,respectively).CONCLUSION:TBX21-1993 polymorphism might contribute to the risk of gastric cancer,especially to the distant metastasis.

外文关键词：

TBX21 geneGastric cancerPolymorphismGenetic susceptibilityAssociation analysis

作者：

Le-Hui Zhang、Qin Li、Peng Li、Sheng-Tao Zhu、Jing Wang、Hong-Li Yang、Chang-Qing Xu

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作者单位：

Department of Epidemiology and Health Statistics, School of Public Health and Family Medicine,Capital Medical University, Beijing 100069, China

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Department of Gastroenterology, Qianfoshan Hospital, Shandong University, Jinan 250014,Shandong Province, China

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基金：

Supported by National Natural Science Foundation

项目编号：

81000187

出版年：

2012

DOI：

10.3748/wjg.v18.i10.1117

世界胃肠病学杂志(英文版)

太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI

影响因子：1.001

ISSN：1007-9327

年,卷(期)：2012.18(10)

参考文献量26