首页|Interleukin-8, a promising predictor for prognosis of pancreatic cancer

Interleukin-8, a promising predictor for prognosis of pancreatic cancer

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
AIM:To investigate the value of interleukin-8 (IL-8),a pro-inflammatory chemokine,in predicting the prognosis of pancreatic cancer.METHODS:Expression of IL-8 and its receptor CXCR1 was assessed by immunohistochemistry in pancreatic cancer and chronic pancreatitis samples.Enzyme-linked immunosorbent assay was used to detect the serum IL-8 levels in pancreatic cancer patients.Human pancreatic cancer tissues were heterotopically transplanted to the immune-deficiency mice to evaluate the effect of serum IL-8 on the tumorigenesis of the cancer samples.RESULTS:IL-8 and CXCR1 proteins were both overexpressed in pancreatic adenocarcinoma samples (55.6％ and 65.4％,respectively) compared with the matched para-cancer tissues (25.9％ and 12.3％,P ＜ 0.01),or chronic pancreatitis (0％ and 25％,P ＜0.05).Serum IL-8 levels in pancreatic cancer patients (271.1 ± 187.7 ng/mL) were higher than in other digestive system tumors,such as gastric cancer (41.77 ±9.11 ng/mL,P =0.025),colorectal carcinoma (78.72 ±80.60 ng/mL,P =0.032) and hepatocellular carcinoma (59.60 ± 19.80 ng/mL,P =0.016).In vivo tumorigenesis analysis further proved that tumor tissues from patients with higher serum IL-8 levels grew faster than those with lower IL-8 levels.CONCLUSION:IL-8 can be a fine serum marker for predicting the prognosis pancreatic cancer.

Pancreatic cancerInterleukin-8CXCR1ImmunohistochemistryTumor implantationEnzyme-linked immunosorbent assay

Ying Chen、Min Shi、Guan-Zhen Yu、Xiao-Ran Qin、Gang Jin、Peng Chen、Ming-Hua Zhu

展开 >

Department of Pathology,Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Department of Oncology, Changzheng Hospital,Second Military Medical University, Shanghai 200433, China

Shanghai Chempartner Co., Ltd., Shanghai 201203, China

Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200433, China

展开 >

National Key Project of Scientific and Technical Supporting Programs of China国家自然科学基金国家自然科学基金

2006BAI02A143077099630901776

2012

10.3748/wjg.v18.i10.1123

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(10)
  • 10
  • 32