首页|Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population
Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population
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NETL
NSTL
万方数据
维普
AIM:To investigate toll-like receptor 2 (TLR2)-196 to -174 del,and TLR4 (+896A/G rs4986790 and +1196C/ T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking,alcohol intake and Helicobacterpylori infection.METHODS:In this case-control study,polymorphism at TLR2-196 to-174 del was investigated by using the allele-specific polymerase chain reaction (PCR) method,while the PCR-restriction fragment length polymorphism technique was carried out to identify the TLR4 (rs4986790 and rs4986791) genotypes in 607 Brazilian individuals (208 with chronic gastritis-CG,174 with gastric cancer-GC and 225 controls-C).RESULTS:The single nucleotide polymorphisms TLR4+1196C/T was not associated with risk of chronic gastritis or gastric cancer and the homozygous genotypes TLR4+896GG and TLR4+1196TT were absent in the studied population.However,the frequency of TLR2-196 to-174 ins/del + del/del and TLR4+896AG genotypes was significantly higher (P ＜ 0.01 and P =0.01,respectively) in the cancer group (33.4％ and 11.5％,respectively) than in the control group (16.9％ and 4.5％,respectively).It was also observed that the G-C haplotype of the TLR4+896A/G+1196C/T (P =0.02) and the combination of variant alleles of the TLR2/TLR4+896G (P =0.02) are associated with susceptibility to gastric cancer.In addition,the multiple logistic regression showed that male gender [odds ratio (OR) =2.70; 95％ CI:1.66-4.41; P ＜ 0.01],alcohol intake (OR =2.93; 95％ CI:1.76-4.87; P ＜ 0.01),TLR2-196 to-174 del (OR =2.64; 95％ CI:1.56-4.44;P ＜ 0.01) and TLR4+896G (OR =3.19; 95％ CI:1.34-7.61; P ＜ 0.01) polymorphisms were associated with a higher susceptibility to developing this neoplasm.CONCLUSION:Our data indicate that TLR2-196 to -174 del and TLR4+896G may increase the risk of gastric cancer in a Brazilian population.
NETL
NSTL
万方数据
维普
