首页|Adenoma incidence decreases under the effect of polypectomy

Adenoma incidence decreases under the effect of polypectomy

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AIM:To investigate whether,under the influence of polypectomy,the incidence of adenoma decreases with age.METHODS:Consecutive patients with colonic adenomas identified at index colonoscopy were retrospectively selected if they had undergone three or more complete colonoscopies,at least 24 mo apart.Patients who had any first-degree relative with colorectal cancer were excluded.Data regarding number of adenomas at each colonoscopy,their location,size and histological classification were recorded.The monthly incidence density of adenomas after the index examination was estimated for the study population,by using the person-years method.Baseline adenomas were excluded from incidence calculations but their characteristics were correlated with recurrence at follow-up,using the x2 test.RESULTS:One hundred and fifty-six patients were included (109 male,mean age at index colonoscopy 56.8 ± 10.3 years),with follow-up that ranged from 48 to 232 mo.No significant correlations were observed between the number,the presence of villous component,or the size of adenomas at index colonoscopy and the presence of adenomas at subsequent colonoscopies (P =0.49,0.12 and 0.78,respectively).The incidence of colonic adenomas was observed to decay from 1.4％person-months at the beginning of the study to values close to 0％,at 12 years after index colonoscopy.CONCLUSION:Our results suggest the sporadic formation of adenomas occurs within a discrete period and that,when these adenomas are removed,all neoplasia-prone clones may be extinguished.

Colorectal cancerColorectal adenomaIncidenceAgePolypectomy

Isadora Rosa、Paulo Fidalgo、José Soares、Susana Vinga、Carla Oliveira、Jo(a)o P Silva、Susana M Ferro、Paula Chaves、António G Oliveira、Carlos N Leit(a)o

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Gastroenterology Department, Instituto Portugu(e)s de Oncologia de Lisboa Francisco Gentil, EPE, 1099-023 Lisboa, Portugal

Faculdade de Ci(e)ncias da Saúde da Universidade da Beira Interior, 6200-506 Covilh(a), Portugal

Gastroenterology Department, Hospital de Santo António, EPE, 4099-001 Porto, Portugal

Instituto de Engenharia de Sistemas e Computadores: Investigac(a)o e Desenvolvimento, 1000-029 Lisboa,Portugal

Biostatistics Department, Faculdade de Ci(e)ncias Médicas, 1169-056 Lisboa, Portugal

Hospital de Santo António, EPE, 4099-001 Porto, Portugal

Pathology Department, Instituto Portugu(e)s de Oncologia de Lisboa Francisco Gentil, EPE, 1099-023 Lisboa,Portugal

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2012

10.3748/wjg.v18.i11.1243

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(11)
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