首页|CCL7 and CCL21 overexpression in gastric cancer is associated with lymph node metastasis and poor prognosis

CCL7 and CCL21 overexpression in gastric cancer is associated with lymph node metastasis and poor prognosis

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AIM:TO investigate how a complex network of CC chemokine ligands (CCLs) and their receptors influence the progression of tumor and metastasis.METHODS:In the present study,we used immunohistochemistry to examine the expression of CCL7,CCL8 and CCL21 in 194 gastric cancer samples and adjacent normal tissues.We analyzed their correlation with tumor metastasis,clinicopathologic parameters and clinical outcome.RESULTS:We found that the higher expression of CCL7 and CCL21 in cancer tissues than in normal tissues was significantly correlated with advanced depth of wall invasion,lymph node metastasis and higher tumor node metastasis stage.Moreover,Kaplan-Meier survival analysis revealed that CCL7 and CCL21 overexpression in cancer tissues was correlated with poor prognosis.CONCLUSION:These results suggest that overexpression of these two CC chemokine ligands is associated with tumor metastasis and serves as a prognostic factor in patients with gastric cancer.

CC chemokineChemokine ligand 7Chemokine ligand 21Gastric cancerLymph node metastasisPoor prognosis

Tsann-Long Hwang、Li-Yu Lee、Chee-Chan Wang、Ying Liang、Shu-Fang Huang、Chi-Ming Wu

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Department of Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan

Department of Medicine, Chang Gung University, Taoyuan 333, Taiwan

Department of Pathology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan

Department of Cosmetic Science, Vanung University, Chungli 320, Taiwan

Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan

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National Science CouncilVanung University,Taiwan

NSC 98-2314-B-238-001VIT-98-CM-01

2012

10.3748/wjg.v18.i11.1249

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(11)
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