首页|Bacterial flora concurrent with Helicobacter pylori in the stomach of patients with upper gastrointestinal diseases

Bacterial flora concurrent with Helicobacter pylori in the stomach of patients with upper gastrointestinal diseases

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AIM:To investigate the non-Helicobacter pylori (H.pylorl) bacterial flora concurrent with H.py/ori infection.METHODS:A total of 103 gastric biopsy specimens from H.py/ori positive patients were selected for bacterial culture.All the non-H.py/ori bacterial isolates were identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS).RESULTS:A total of 201 non-H.py/ori bacterial isolates were cultivated from 67 (65.0％) of the 103 gastric samples,including 153 isolates identified successfully at species level and 48 at genus level by MALDI-TOF MS.The dominant species were Streptococcus,Neisseria,Rothia and Staphylococcus,which differed from the predominantly acid resistant species reported previously in healthy volunteers.The prevalence of non-H.pylori bacteria was higher in non-ulcer dyspepsia group than in gastric ulcer group (100％ vs 42.9％,P ＜ 0.001).Six bacterial species with urease activity (Staphylococcus epidermidis,Staphylococcus warneri,Staphylococcus capitis,Staphylococcus aureus,Brevibacterium spp.and Klebsiella pneumoniae) were also isolated.CONCLUSION:There is a high prevalence of the non-H.pylori bacteria concurrent with H.pylori infection,and the non-H.pylori bacteria may also play important as-yet-undiscovered roles in the pathogenesis of stomach disorders.

Non-Helicobacter pyloriBacterial floraGastrointestinal diseasesMatrix-assisted laser desorption ionization time-of-flight mass spectrometry

Yuan Hu、Li-Hua He、Di Xiao、Guo-Dong Liu、Yi-Xin Gu、Xiao-Xia Tao、Jian-Zhong Zhang

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State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

major projects of infectious disease prevention and control in China,including AIDS and viral hepatitismajor projects of infectious disease prevention and control in China,including AIDS and viral hepatitis

2008ZX10004-002.2009ZX10603

2012

10.3748/wjg.v18.i11.1257

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(11)
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