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Magnetic resonance imaging: A new tool for diagnosis of acute ischemic colitis?

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AIM:To define the evolution of ischemic lesions with 7T magnetic resonance imaging (7T-MRI) in an animal model of acute colonic ischemia.METHODS:Adult Sprague-Dawley rats were divided into two groups.Group I underwent inferior mesenteric artery (IMA) ligation followed by macroscopic observations and histological analysis.In group Ⅱ,7T-MRI was performed before and after IMA ligation and followed by histological analysis.RESULTS:Morphological alterations started to develop 1 h after IMA ligation,when pale areas became evident in the splenic flexure mesenteny and progressively worsened up to 8 h thereafter,when the mesentery was less pale,and the splenic flexure loop appeared very dark.The 7T-MRI results reflected these alterations,showing a hyperintense signal in both the intraperitoneal space and the colonic loop wall 1 h after IMA ligation; the latter progressively increased to demonstrate a reduction in the colonic loop lumen at 6 h.Eight hours after IMA ligation,MRI showed a persistent colonic mural hyperintensity associated with a reduction in peritoneal free fluid.The 7T-MRI findings were correlated with histological alterations,varying from an attenuated epithelium with glandular apex lesions at 1 h to coagulative necrosis and loss of the surface epithelium detected 8 h after IMA ligation.CONCLUSION:MRI may be used as a substitute for invasive procedures in diagnosing and grading acute ischemic colitis,allowing for the early identification of pathological findings.

Ischemic colitisAnimal modelsSprague-Dawley ratsMagnetic resonance imagingHistopathology

Francesca Iacobellis、Daniela Berritto、Francesco Somma、Carlo Cavaliere、Marco Corona、Santolo Cozzolino、Franco Fulciniti

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Institute of Radiology, Second University of Naples, 80138 Naples, Italy

Biotechnology Center, A.O.R.N.Cardarelli, 80131 Naples, Italy

S.S.D.di Citopatologia, A.F.di Anatomia Patologica, Istituto Nazionale Tumori "Fondazione G.Pascale",80131 Naples, Italy

2012

10.3748/wjg.v18.i13.1496

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(13)
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