首页|Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease

Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease

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AIM:To evaluate the noninvasive parameters and hepatic fibrosis scores in obese children with nonalcoholic fatty liver disease (NAFLD).METHODS:A total of 77 children diagnosed with NAFLD via liver biopsy were included and divided into 2 subgroups according to the histopathologic staging of hepatic fibrosis:mild (stage 0-1) vs significant fibrosis (stage 2-4).Clinical and laboratory parameters were evaluated in each patient.The aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio,AST/platelet ratio index (APRI),PGA index,Forns index,FIB-4,NAFLD fibrosis score,and pediatric NAFLD fibrosis index (PNFI) were calculated.RESULTS:No clinical or biochemical parameter exhibited a significant difference between patients with mild and significant fibrosis.Among noninvasive hepatic fibrosis scores,only APRI and FIB4 revealed a significant difference between patients with mild and significant fibrosis (APRI:0.67 ± 0.54 vs 0.78 ± 0.38,P =0.032and FIB4:0.24 ± 0.12 vs 0.31 ± 0.21,P =0.010).The area under the receiving operating characteristic curve of FIB4 was 0.81,followed by Forns index (0.73),APRI (0.70),NAFLD fibrosis score (0.58),AST/ALT ratio (0.53),PGA score (0.45),and PNFI (0.41).CONCLUSION:APRI and FIB4 might be useful noninvasive hepatic fibrosis scores for predicting hepatic fibrosis in children with NAFLD.

Fatty liverHepatic fibrosisNoninvasiveObesityChild

Hye Ran Yang、Hae Ryoung Kim、Myung Jin Kim、Jae Sung Ko、Jeong Kee Seo

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Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam-si, Gyonggi-do 463-707,South Korea

Department of Pediatrics, Seoul National University College of Medicine, Seoul 110-744, South Korea

Department of Pathology, Seoul National University Bundang Hospital, Seongnam-si, Gyonggi-do 464-894,South Korea

2012

10.3748/wjg.v18.i13.1525

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(13)
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