首页|Clinical implication of 14-3-3 epsilon expression in gastric cancer

Clinical implication of 14-3-3 epsilon expression in gastric cancer

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AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3ε in gastric carcinogenesis.METHODS:14-3-3ε protein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.RESULTS:Authors observed a significant reduction of 14-3-3ε protein expression in gastric cancer (GC) samples compared to their matched non-neoplastic tissue.Reduced levels of 14-3-3ε were also associated with diffuse-type GC and early-onset of this pathology.Our data suggest that reduced 14-3-3ε may have a role in gastric carcinogenesis process.CONCLUSION:Our results reveal that the reduced 14-3-3ε expression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcinogenesis process.

Gastric cancer14-3-3 epsilonYWHAEGene expressionProtein expression

Mariana Ferreira Leal、Danielle Queiroz Calcagno、S(a)mia Demachki、Paulo Pimentel Assump(c)(a)o、Roger Chammas、Rommel Rodríguez Burbano、Marília de Arruda Cardoso Smith

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Genetics Division, Department of Morphology and Genetic, Federal University of S(a)o Paulo, S(a)o Paulo 04023-900, Brazil

Pathology Service, Jo(a)o de Barros Barreto University Hospital, Federal University of Pará, Belém 60673-000,Brazil

Surgery Service, Jo(a)o de Barros Barreto University Hospital, Federal University of Pará Belém 60673-000, Brazil

Laboratory of Experimental Oncology, School of Medicine, University of S(a)o Paulo, S(a)o Paulo 01246-903, Brazil

Human Cytogenetics Laboratory, Institute of Biological Sciences, Federal University of Pará,Belém 66073-000, Brazil

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Conselho Nacional de Desenvolvimento Científico e Tecnol6gico (CNPq; Chammas R,Smith MAC and Burbano RR) and Funda©(a)o de Ampar

2012

10.3748/wjg.v18.i13.1531

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(13)
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