首页|Prognostic significance of PTEN, Ki-67 and CD44s expression patterns in gastrointestinal stromal tumors
Prognostic significance of PTEN, Ki-67 and CD44s expression patterns in gastrointestinal stromal tumors
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NETL
NSTL
万方数据
AIM:To develop a prognostic approach for gastrointestinal stromal tumors (GISTs) using a cluster of indicators and follow-up information.METHODS:One hundred and four GISTs that had not been subjected to targeted therapies were collected and classified by NIH risk assessment and anatomic location.By immunohistochemistry,the expressions of PTEN,Ki-67,CD44s matrix metalloproteinase (MMP)-9 and TIMP-1 were detected on tissue microarray.Univariate and multimarker survival analyses were performed and then a COX hazard proportion model was constructed to evaluate a cluster of predictors of GIST.RESULTS:Our data showed small intestinal GIST are more aggressive than gastric GIST.The NIH risk assessment correlated with disease-free survival for either gastric GIST or small intestinal GIST.Immunohistochemical analysis revealed that Ki-67 labeling indexes (LIs) ＜ 5％ predicted higher disease-specific survival (DSS) in gastric and small intestinal GIST.CD44s positivity and PTEN LIs ≥ 50％ correlated with higher DSS in gastric GIST.MMP-9 and TIMP-1 had no correlation with survival.Multimarker analysis revealed that the expression pattern of PTEN LIs ≥ 50％ combined with Ki-67 LIs ＜ 5％ and CD44s positivity reliably predicted favorable outcomes for gastric GIST (P =0.009),as did the combination of PTEN LIs ≥ 50％ and Ki-67 LIs ＜5％ for small intestinal GIST (P =0.011).Authors also found that high NIH risk grade was correlated with DSS in patients with gastric GIST and disease-free survival in patients with small intestinal GIST.CONCLUSION:PTEN LIs ≥ 50％,Ki-67 LIs ＜ 5％ and CD44s positivity provides an accurate,favorable prognosis for gastric GIST.PTEN LIs ≥ 50％ and Ki-67 LIs ＜ 5％ does the same for small intestinal GIST.Ki-67 LIs enhances the NIH assessment.
NETL
NSTL
万方数据
