首页|Propofol vs midazolam plus fentanyl for upper gastrointestinal endomicroscopy: A randomized trial
Propofol vs midazolam plus fentanyl for upper gastrointestinal endomicroscopy: A randomized trial
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AIM:To compare the endomicroscopic image quality of integrated confocal laser endomicroscopy (iCLE) and sedation efficacy of propofol vs midazolam plus fentanyl (M/F).METHODS:Consecutive outpatients undergoing iCLE were prospectively recruited and randomized to the propofol group (P group) or M/F group.The patient,performing endoscopist and endoscopic assistant were blinded to the randomization.The quality of endomicro<scopic images and anesthetic efficacy outcomes were blindly evaluated after iCLE examination.RESULTS:There were significantly more good quality endomicroscopic images in the propofol group than in the M/F group (72.75％ vs 52.89％,P ＜ 0.001).The diagnostic accuracy for upper gastrointestinal mucosal lesions using confocal laser endomicroscopy favors the P group,although this did not reach statistical significance.Adverse events and patient assessment were not significantly different for M/F vs propofol except for more frequent intraprocedural recall with M/F.Procedure duration and sedation times were significantly longer in the M/F group,while the scores of endoscopist,anesthetist and assistant assessment were all significantly better in the P group.CONCLUSION:Sedation with propofol might increase the proportion of good quality endomicroscopic images,and may result in improved procedural efficacy and diagnostic accuracy during iCLE examination.
Confocal laser endomicroscopyConscious sedationRandomized trialSensitivity and specificityImage quality
Xiu-Li Zuo、Zhen Li、Xiao-Ping Liu、Chang-Qing Li、Rui Ji、Peng Wang、Cheng-Jun Zhou、Han Liu、Yan-Qing Li
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Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China
Department of Anesthesiology, Qilu Hospital,Shandong University, Jinan 250012, Shandong Province, China
Department of Pathology, the Second Affiliated Hospital, Shandong University, Jinan 250033, Shandong Province, China
Ministry of Health of China (2010)Shandong Province Science and Technology CommitteeGraduate Independent Innovation Fund of Shandong University
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