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Gastrointestinal and hepatic complications of hematopoietic stem cell transplantation

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Recognition and management of gastrointestinal and hepatic complications of hematopoietic stem cell transplantation has gained increasing importance as indications and techniques of transplantation have expanded in the last few years.The transplant recipient is at risk for several complications including conditioning chemotherapy related toxicities,infections,bleeding,sinusoidal obstruction syndrome,acute and chronic graftversus-host disease (GVHD) as well as other long-term problems.The severity and the incidence of many complications have improved in the past several years as the intensity of conditioning regimens has diminished and better supportive care and GVHD prevention strategies have been implemented.Transplant clinicians,however,continue to be challenged with problems arising from human leukocyte antigen-mismatched and unrelated donor transplants,expanding transplant indications and age-limit.This review describes the most commonly seen transplant related complications,focusing on their pathogenesis,differential diagnosis and management.

Stem cell transplantationGraft-versus-host diseaseSinusoidal obstruction syndromeComplications

Hande H Tuncer、Naveed Rana、Cannon Milani、Angela Darko、Samer A Al-Homsi

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Division of Hematological Malignancies and Blood and Marrow Transplantation, Roger Williams Medical Center, Providence, RI 02908, United States

Samer A Al-Homsi, Boston University School of Medicine,Boston, MA 02203, United States

Department of Pathology, Roger Williams Medical Center, Providence, RI 02908, United States

2012

10.3748/wjg.v18.i16.1851

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(16)
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