首页|Antithrombin Ⅲ injection via the portal vein suppresses liver damage

Antithrombin Ⅲ injection via the portal vein suppresses liver damage

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AIM:To investigate the effects of antithrombin Ⅲ (AT Ⅲ) injection via the portal vein in acute liver failure.METHODS:Thirty rats were intraperitoneally challenged with lipopolysaccharide (LPS) and D-galactosamine (GaiN) and divided into three groups:a control group; a group injected with AT Ⅲ via the tail vein; and a group injected with AT Ⅲ via the portal vein.AT Ⅲ (50U/kg body weight) was administrated 1 h after challenge with LPS and GAIN.Serum levels of inflammatory cytokines and fibrin degradation products,hepatic fibrin deposition,and hepatic mRNA expression of hypoxiarelated genes were analyzed.RESULTS:Serum levels of alanine aminotransferase,tumor necrosis factor-o and interleukin-6 decreased significantly following portal vein AT Ⅲ injection compared with tail vein injection,and control rats.Portal vein AT Ⅲ injection reduced liver cell destruction and decreased hepatic fibrin deposition.This treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme oxygenase-1.CONCLUSION:A clinically acceptable dose of AT Ⅲ injection into the portal vein suppressed liver damage,probably through its enhanced anticoagulant and antiinflammatory activities.

Antithrombin ⅢAcute liver failureIntravascular coagulationPortal vein

Masavuki Mivazaki、Masaki Kato、Masatake Tanaka、Kosuke Tanaka、Shinichiro Takao、Motoyuki Kohjima、Tetsuhide Ito、Munechika Enjoji、Makoto Nakamuta、Kazuhiro Kotoh、Ryoichi Takayanagi

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Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University,Fukuoka 812-8582, Japan

Department of Gastroenterology, Kyushu Medical Center, National Hospital Organization, Fukuoka 810-0065, Japan

Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan

2012

10.3748/wjg.v18.i16.1884

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(16)
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