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Stem cell differentiation and human liver disease

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Human stem cells are scalable cell populations capable of cellular differentiation.This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells.Such an approach has the potential to improve our understanding of human biology and treating disease.In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases.In recent years,efficient hepatic differentiation from human stem cells has been achieved by several research groups including our own.In this review we provide an overview of the field and discuss the future potential and limitations of stem cell technology.

DifferentiationPluripotent stem cellsHepatocyte-like cellsLiver developmentPolymer chemistryRegenerative medicineTransplantationBio-artificial liver

Wen-Li Zhou、Claire N Medine、Liang Zhu、David C Hay

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Department of Gastroenterology,Changzheng Hospital, Second Military Medical University of China, Shanghai 200003, China

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, United Kingdom

A RCUK fellowshipA grant from the Edinburgh Bioquarter,to Medine CN China Scholarship Council

EP/E500145/12010658022

2012

10.3748/wjg.v18.i17.2018

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(17)
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