Age, smoking and overweight contribute to the development of intestinal metaplasia of the cardia

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外文摘要：AIM:To assess the role of Helicobacterpylori (H.pylori),gastroesophageal reflux disease (GERD),age,smoking and body weight on the development of intestinal metaplasia of the gastric cardia (IMC).METHODS:Two hundred and seventeen patients scheduled for esophagogastroduodenoscopy were enrolled in this study.Endoscopic biopsies from the esophagus,gastroesophageal junction and stomach were evaluated for inflammation,the presence of H.pylori and intestinal metaplasia.The correlation of these factors with the presence of IMC was assessed using logistic regression.RESULTS:IMC was observed in 42％ of the patients.Patient age,smoking habit and body mass index (BMI)were found as potential contributors to IMC.The risk of developing IMC can be predicted in theory by combining these factors according to the following formula:Risk of IMC =a + s-2B where a =2,...6 decade of age,s =0for non-smokers or ex-smokers,1 for ＜ 10 cigarettes/d,2 for ＞ 10 cigarettes/d and B =0 for BMI ＜ 25 kg/m2 (BMI ＜ 27 kg/m2 in females),1 for BMI ＞ 25 kg/m2 (BMI ＞ 27 kg/m2 in females).Among potential factors associated with IMC,H.pylori had borderline significance (P =0.07),while GERD showed no significance.CONCLUSION:Age,smoking and BMI are potential factors associated with IMC,whileH.pylori and GERDshow no significant association.IMC can be predicted in theory by logistic regression analysis.

外文关键词：

EndoscopyGastroesophageal reflux diseaseMetaplasiaHelicobacter pyloriObesitySmoking

作者：

Christian Felley、Hanifa Bouzourene、Marianne Bründler G VanMelle、Antoine Hadengue、Pierre Michetti、Gian Dorta、Laurent Spahr、Emiliano Giostra、Jean Louis Frossard

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作者单位：

Service of Gastroenterology, University Hospital, 1000 Lausanne, Switzerland

Institute of Pathology, University Hospital,1000 Lausanne, Switzerland

Institute of Social and Preventive Medicine, University of Lausanne, 1000 Lausanne,Switzerland

Service of Gastroenterology, Geneva University Hospital, 1211 Geneva, Switzerland

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出版年：

2012

DOI：

10.3748/wjg.v18.i17.2076

世界胃肠病学杂志(英文版)