首页|Antibiotic resistance and cagA gene correlation: A looming crisis of Helicobacter pylori

Antibiotic resistance and cagA gene correlation: A looming crisis of Helicobacter pylori

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
AIM:To determine antibiotic resistance of Helicobacter pylori (H.pylori) in Pakistan and its correlation with host and pathogen associated factors.METHODS:A total of 178 strains of H.pylori were isolated from gastric biopsies of dyspeptic patients.Susceptibility patterns against first and second-line antibiotics were determined and trends of resistance were analyzed in relation to the sampling period,gastric conditions and cagA gene carriage.The effect of cagA gene on the acquisition of resistance was investigated by mutant selection assay.RESULTS:The observations showed that monoresistant strains were prevalent with rates of 89％ for metronidazole,36％ for clarithromycin,37％ for amoxicillin,18.5％ for ofloxacin and 12％ for tetracycline.Furthermore,clarithromycin resistance was on the rise from 2005 to 2008 (32％ vs 38％,P =0.004) and it is significantly observed in non ulcerative dyspeptic patients compared to gastritis,gastric ulcer and duodenal ulcer cases (53％ vs 20％,18％ and 19％,P =0.000).On the contrary,metronidazole and ofloxacin resistance were more common in gastritis and gastric ulcer cases.Distribution analysis and frequencies of resistant mutants in vitro correlated with the absence of cagA gene with metronidazole and ofloxacin resistance.CONCLUSION:The study confirms the alarming levels of antibiotic resistance associated with the degree of gastric inflammation and cagA gene carriage in H.pylori strains.

Helicobacter pyloriAntibiotic resistancecagAPakistanClarithromycinMetronidazoleFluoroquinolones

Adnan Khan、Amber Farooqui、Hamid Manzoor、Syed Shakeel Akhtar、Muhammad Saeed Quraishy、Shahana Urooj Kazmi

展开 >

Immunology and Infectious Diseases Research Laboratory, Department of Microbiology, University of Karachi, University Road, Karachi 75270, Pakistan

Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong 515041, China

Department of Surgery, Civil Hospital, Karachi 74200, Pakistan

Department of Medicine, Civil Hospital, Karachi 74200, Pakistan

展开 >

2012

10.3748/wjg.v18.i18.2245

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(18)
  • 16
  • 31