首页|Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection
Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection
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AIM:To compare the effectiveness of sequential therapy for Helicobacter pylori (H.pylori） infection with that of triple therapy of varying durations.METHODS:The 460 patients enrolled in this study had H.pylori-associated gastritis or a gastric or duodenal ulcer.After screening,H.pylori-infected patients were randomly assigned to receive either conventional triple therapy for 7,10 or 14 d,or a new 10-d sequential therapy.Each of the 4 treatment groups included 115 patients.The outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and histology.RESULTS:The overall eradication rate was 81.0％,and eradication rates were 75.7％ for 7-d conventional triple therapy,81.9％ for 10-d conventional triple therapy,84.4％ for 14-d conventional triple therapy,and 82.0％ for 10-d sequential therapy.Neither intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy (P =0.416 and P =0.405,respectively).CONCLUSION:There are no significant differences between 10-d sequential eradication therapy for H.pylori and any duration of standard triple treatment in Korean patients.
Hyuk Soon Choi、Hoon Jai Chun、Sang Hoon Park、Bora Keum、Yeon Seok Seo、Yong Sik Kim、Yoon-Tae Jeen
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul 136-705, South Korea
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