首页|Salvage liver transplantation in the treatment of hepatocellular carcinoma: A Meta-analysis
Salvage liver transplantation in the treatment of hepatocellular carcinoma: A Meta-analysis
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NETL
NSTL
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维普
AIM:To evaluate survival and recurrence after salvage liver transplantation (SLT) for the treatment of hepatocellular carcinoma (HCC) compared with primary liver transplantation (PLT) using a meta-analysis.METHODS:Literature on SLT versus PLT for the treatment of HCC published between 1966 and July 2011 was retrieved.A meta-analysis was conducted to estimate pooled survival and disease-free rates.A fixed or random-effect model was established to collect the data.RESULTS:The differences in overall survival and disease-free survival rates at 1-year,3-year and 5-year survival rates were not statistically significant between SLT group and PLT group (P ＞ 0.05).After stratifying the various studies by donor source and Milan criteria,we found that:(1) Living donor liver transplantation recipients had significantly higher 1-year survival rate,lower 3-year and 5-year survival rates compared with deceased-donor liver transplantation (DDLT) recipients.And in DDLT recipients they had better 1-year and 5-year disease-free survival rate in SLT group; and (2)No difference was seen in 1-year,3-year and 5-year survival rates between two groups who beyond Milan criteria at the time of liver transplantation.CONCLUSION:SLT can be effectively performed for patients with recurrence or deterioration of liver function after hepatectomy for HCC.It does not increase the perioperative mortality and has a similar long-term survival rates compared to PLT.
Department of Liver and Vascular Surgery, Center of Liver Transplantation,West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
NETL
NSTL
万方数据
维普
