Globus pharyngeus: A review of its etiology, diagnosis and treatment

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外文摘要：Globus is a persistent or intermittent non-painful sensation of a lump or foreign body in the throat.It is a commonly encountered clinical condition that is usually long-lasting,difficult to treat,and has a tendency to recur.Furthermore,due to the uncertain etiology of globus,it remains difficult to establish standard investigation and treatment strategies for affected patients.As a first step for managing globus,careful history taking and nasolaryngoscopy are essential.Given the benign nature of the condition and the recent notion that gastroesophageal reflux disease is a major cause of globus,empirical therapy with a high dose of proton pump inhibitors is reasonable for patients with typical globus.If patients are nonresponsive to this therapy,definitive assessments such as endoscopy,multichannel intraluminal impedance/pH monitoring,and manometry should be considered.Speech and language therapy,anti-depressants,and cognitive-behavioral therapy can be helpful in patients whose symptoms persist despite negative investigations.

外文关键词：

DiagnosisGastroesophageal reflux diseaseGlobusProton pump inhibitorTreatment

作者：

Bong Eun Lee、Gwang Ha Kim

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作者单位：

Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital,Busan 602-739, South Korea

基金：

A Pusan National University Hospital Clinical Research GrantNational R and D Program for Cancer Control,Ministry for Health,Welfare and Family Affairs,Republic of Korea

项目编号：

20110920050

出版年：

2012

DOI：

10.3748/wjg.v18.i20.2462

世界胃肠病学杂志(英文版)

太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI

影响因子：1.001

ISSN：1007-9327

年,卷(期)：2012.18(20)

被引量11
参考文献量123