首页|Cost-benefit analysis of esophageal cancer endoscopic screening in high-risk areas of China
Cost-benefit analysis of esophageal cancer endoscopic screening in high-risk areas of China
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NETL
NSTL
万方数据
维普
AIM:To estimate the cost-benefit of endoscopic screening strategies of esophageal cancer (EC) in high-risk areas of China.METHODS:Markov model-based analyses were conducted to compare the net present values (NPVs) and the benefit-cost ratios (BCRs) of 12 EC endoscopic screening strategies.Strategies varied according to the targeted screening age,screening frequencies,and follow-up intervals.Model parameters were collected from population-based studies in China,published literatures,and surveillance data.RESULTS:Compared with non-screening outcomes,all strategies with hypothetical 100 000 subjects saved life years.Among five dominant strategies determined by the incremental cost-effectiveness analysis,screening once at age 50 years incurred the lowest NPV (international dollar-I＄55 million) and BCR (2.52).Screening six times between 40-70 years at a 5-year interval [i.e.,six times(40)f-strategy] yielded the highest NPV (I＄99 million) and BCR (3.06).Compared with six times(40)fstrategy,screening thrice between 40-70 years at a 10-year interval resulted in relatively lower NPV,but the same BCR.CONCLUSION:EC endoscopic screening is cost-beneficial in high-risk areas of China.Policy-makers should consider the cost-benefit,population acceptance,and local economic status when choosing suitable screening strategies.
Cost-benefit analysisEsophageal cancerEndoscopyScreeningHigh-risk area
Juan Yang、Wen-Qiang Wei、Jin Niu、Zhi-Cai Liu、Chun-Xia Yang、You-Lin Qiao
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Department of Epidemiology, West China School of Public Health, Sichuan University,Chengdu 610041, Sichuan Province, China
Department of Epidemiology,Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Department of Thoracic Surgery, Linzhou Cancer Institute, Linzhou 456550, Henan Province, China
National Science and Technology Pillar Program of the 11th National Five-Year Plan of China
NETL
NSTL
万方数据
维普
