首页|Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors

Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors

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AIM:To investigate the role of expressions of Ki-67,p53,epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) in gastrointestinal stromal tumor (GIST) grading and prognosis.METHODS:Tumor tissue was collected retrospectively from 96 patients with GIST.Antibodies against Ki-67,p53,EGFR and COX-2 were used for immunohistochemical staining.Tumor grading was designated according to a consensus system and the staining was quantified in 3 categories for each antibody in the statistical analysis.RESULTS:The Ki-67 expression in GISTs was significantly associated with the size of the tumors,mitotic rate and the risk of malignancy (x2 =15.51,P =0.02;x2=22.27,P ＜ 0.001; x2=20.05; P ＜ 0.001).The p53 expression was also significantly correlated with mitotic rate and the risk of malignancy (x2 =9.92,P =0.04; x2 =9.97; P =0.04).Over-expression of Ki-67was strongly correlated with poor survival (x2 =10.44,P =0.006),but no correlation was found between the expression of p53,EGFR or COX-2 and survival.Multivariate analysis further demonstrated that Ki-67expression (relative risk =15.78,95％ CI:4.25-59.37)could be used as an independent prognostic value for GIST patients.Adjuvant imatinib therapy could improve clinical outcomes in the patients with high risk and intermediate risk of recurrence after complete tumor resections (median survival time:52 mo vs 37 mo,x2 =7.618,P =0.006).CONCLUSION:Our results indicated that the expression of Ki-67 could be used as an independent prognostic factor for GIST patients.

Gastrointestinal stromal tumorPrognosisKi-67 alterationp53Epidermal growth factor receptor

Jing Jiang、Mei-Shan Jin、Jian Suo、Yin-Ping Wang、Liang He、Xue-Yuan Cao

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Division of Clinical Epidemiology, Jilin University First Hospital, Changchun 130021, Jilin Province, China

Division of Pathology, Jilin University First Hospital, Changchun 130021, Jilin Province,China

Department of Gastrointestinal Surgery, Jilin University First Hospital, Changchun 130021, Jilin Province, China

2012

10.3748/wjg.v18.i20.2569

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(20)
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