首页|Eradication of Helicobacter pylori increases childhood growth and serum acylated ghrelin levels

Eradication of Helicobacter pylori increases childhood growth and serum acylated ghrelin levels

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AIM:To determine whether Helicobacterpylori (H.pylorl)-infected children have reduced body weight (BW) and height (BH) growth,and if H.pylori eradication may restore growth while improving serum acylated ghrelin.METHODS:This longitudinal cohort study with oneyear follow-up enrolled 1222 children aged 4 to 12 years old into an observation cohort (18 with and 318 without H.pylori) and intervention cohort (75 with and 811 without).The 7-d triple therapy was used for eradication in the intervention cohort.The net increases of BW and BH as well serum acylated ghrelin after oneyear follow-up were compared between successful eradicated H.pylori-infected children and controls.RESULTS:In the observation cohort,the H.pyloriinfected children had lower z score of BW (-1.11 ± 0.47vs 0.35± 0.69,P =0.01) and body mass index (BMI)(0.06 ± 0.45 vs 0.44± 0.73,P =0.02) at enrollment and lower net BW gain after one-year follow-up (3.3 ±2.1 kg vs 4.5 ± 2.4 kg,P =0.04) than the non-infected controls.In the intervention cohort,the H.pyloriinfected children had lower z score of BMI (0.25 ± 1.09vs 0.68 ± 0.87,P =0.009) and serum acylated ghrelin levels (41.8 ± 35.6 pg/mL vs 83.6 ± 24.2 pg/mL,P ＜0.001) than the non-infected controls.In addition to restoring decreased serum ghrelin levels (87.7 ± 38.0pg/mL vs 44.2 ± 39.0 pg/mL,P ＜ 0.001),the H.pyloriinfected children with successful eradication had higher net gains (P ＜ 0.05) and increase of z scores (P ＜ 0.05)of both BW and BH as compared with non-infected controls after one-year follow-up.CONCLUSION:H.pylori-infected children are associated with low serum acylated ghrelin and growth retardation.Successful eradication of H.pylori restores ghrelin levels and increases growth in children.

ChildClinical trialGhrelinGrowth retardationHelicobacter pylori

Yao-Jong Yang、Bor-Shyang Sheu、Hsiao-Bai Yang、Cheng-Chan Lu、Ching-Chun Chuang

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Departments of Pediatrics and Institute of Clinical Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan, China

Departments of Internal Medicine and Institute of Clinical Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan, China

Ton-Yen General Hospital, Hsinchu County 70428 Taiwan, China

Department of Pathology,Medical College, National Cheng Kung University, Tainan 70428, Taiwan, China

Institute of Clinical Medicine, Medical College, National Cheng Kung University, Tainan 70428, Taiwan, China

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Supported by National Cheng Kung University Hospital,Tainan,ChinaSupported by National Cheng Kung University Hospital,Tainan,ChinaSupported by National Cheng Kung University Hospital,Tainan,ChinaDepartment of Health,Taiwan,China

NCKUH96-030DOH99-TD-C-111-003DOH99-TD-C-111-003

2012

10.3748/wjg.v18.i21.2674

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(21)
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