首页|Health-related quality of life evaluated by tumor node metastasis staging system in patients with hepatocellular carcinoma

Health-related quality of life evaluated by tumor node metastasis staging system in patients with hepatocellular carcinoma

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AIM:To investigate and evaluate the change in healthrelated quality of life (HRQoL) by tumor node metastasis (TNM) staging system in patients with hepatocellular carcinoma (HCC).METHODS:A total of 140 patients diagnosed with HCC between June 2008 and April 2009 in our department were enrolled to this study.One hundred and thirty-five (96.5％) patients had liver cirrhosis secondary to hepatitis B virus (HBV) infection,73 (54.07％) of them being HBV DNA positive; the other etiologies of liver cirrhosis were alcoholic liver disease (1.4％),hepatitis C (1.4％)or cryptogenic (0.7％).All subjects were fully aware of their diagnosis and provided informed consent.HRQoL was assessed before treatment using the functional assessment of cancer therapy-hepatobiliary (FACTHep) questionnaire.Descriptive statistics were used to evaluate demographics and disease-specific characteristics of the patients.One-way analysis of variance and independent samples t tests were used to compare the overall FACT-Hep scores and clinically distinct TNM stages.Scores for all FACT-Hep items were analyzed by frequency analyses.The mean scores obtained from the FACT-Hep in different Child-Pugh classes were also evaluated.RESULTS:The mean FACT-Hep scores were reduced significantly from TNM Stage Ⅰ to Stage Ⅱ,Stage ⅢA,Stage ⅢB group (687 ± 39.69 vs 547 ± 42.57 vs 387 ± 51.24 vs 177 ± 71.44,P =0.001).Regarding the physical and emotional well-being subscales,scores decreased gradually from Stage Ⅰ to Stage ⅢB (P =0.002 vs Stage Ⅰ ; P =0.032 vs Stage Ⅱ; P =0.033 vs Stage ⅢA).Mean FACT-Hep scores varied by Child-Pugh class,especially in the subscales of physical well-being,functional well-being and the hepatobiliary cancer (P =0.001 vs Stage Ⅰ; P =0.036 vs Stage Ⅱ ; P =0.032 vs Stage ⅢA).For the social and family well-being subscale,only Stage ⅢB scores were significantly lower as compared with Stage Ⅰ scores (P =0.035).For the subscales of functional well-being and hepatobiliary cancer,there were significant differences for Stages Ⅱ Ⅰ,ⅢA and ⅢB (P =0.002 vs Stage Ⅰ).CONCLUSION:HRQoL of patients with HCC worsens gradually with progression of TNM stages.The most impaired subscales of HRQoL,as measured by FACTHep,were physical and emotional well-being.

Hepatocellular carcinomaTumor node metastasis stagingFunctional assessment of cancer therapy-hepatobiliaryHealth-related quality of lifeCross-sectional study

Cui-Xia Qiao、Xiao-Feng Zhai、Chang-Quan Ling、Qing-Bo Lang、Hui-Juan Dong、Qun Liu、Mou-Duo Li

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Department of Traditional Chinese Medicine, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433,China

Department of Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China

E-Institute of Traditional Chinese Medicine Internal Medicine, Shanghai 200433, China

Supported by Grants from the E-Institute of Shanghai Municipal Education CommissionShanghai Municipal Health Bureau of Traditional Chinese Medicine Research Project Fund 2010-2011

E030082010L052B

2012

10.3748/wjg.v18.i21.2689

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(21)
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