首页|Toxic hepatitis in occupational exposure to solvents

Toxic hepatitis in occupational exposure to solvents

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The liver is the main organ responsible for the metabolism of drugs and toxic chemicals,and so is the primary target organ for many organic solvents.Work activities with hepatotoxins exposures are numerous and,moreover,organic solvents are used in various industrial processes.Organic solvents used in different industrial processes may be associated with hepatotoxicity.Several factors contribute to liver toxicity; among these are:species differences,nutritional condition,genetic factors,interaction with medications in use,alcohol abuse and interaction,and age.This review addresses the mechanisms of hepatotoxicity.The main pathogenic mechanisms responsible for functional and organic damage caused by solvents are:inflammation,dysfunction of cytochrome P450,mitochondrial dysfunction and oxidative stress.The health impact of exposure to solvents in the workplace remains an interesting and worrying question for professional health work.

Work activityHepatotoxicityHepatotoxinOccupational diseaseInflammation

Giulia Malaguarnera、Emanuela Cataudella、Maria Giordano、Giuseppe Nunnari、Giuseppe Chisari、Mariano Malaguarnera

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Research Centre "The Great Senescence", University of Catania, 95100 Catania, Italy

Giulia Malaguarnera, Emanuela Cataudella, Maria Giordano,Mariano Malaguarnera, Research Centre "The Great Senescence", University of Catania, 95100 Catania, Italy

Department of Infective Diseases, Hospital "Garibaldi di Nesima", University of Catania, 95100 Catania,Italy

Microbiology and Clinical Microbiology, Department of Biomedical Science, Hospital Policlinico, Universityof Catania, 95100 Catania, Italy

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2012

10.3748/wjg.v18.i22.2756

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.(22)
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