首页|Simple and reproducible hepatectomy in the mouse using the clip technique

Simple and reproducible hepatectomy in the mouse using the clip technique

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AIM:TO investigate the reliability of massive hepatectomy models by using clip techniques.METHODS:We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction ＞ 70％.The impact of various factors in the different models was also analyzed,including learning curves,operative time,survival curves,and histopathological findings.RESULTS:According to anatomical results,models with 75％,80％,and 90％ hepatectomy produced massive hepatectomy.Learning curves and operative times were most optimal with the clip technique.Each hepatectomy performed using the clip technique produced a reasonable survival curve,and there were no differences in histopathological findings between the suture and clip techniques.CONCLUSION:Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.

HepatectomyAnimal modelClipMicrosurgerySurgical technique

Tomohide Hori、Norifumi Ohashi、Feng Chen、Ann-Marie T Baine、Lindsay B Gardner、Toshiyuki Hata,、Shinji Uemoto,、Justin H Nguyen

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Department of Neuroscience, Mayo Clinic in Florida,Jacksonville, FL 32224, United States

Shinji Uemoto, Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan

Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan

Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan

Justin H Nguyen, Division of Transplant Surgery, Department of Transplantation, Mayo Clinic in Florida, Jacksonville, FL 32224,United States

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Grants to Justin H Nguycn from the Deason Foundation,Sandra and Eugene Davenport,Mayo ClinicGrants to Justin H Nguycn from the Deason Foundation,Sandra and Eugene Davenport,Mayo Clinicpartial grant to Tomohide Hori from the Uehara Memorial Foundationpartial grant to Tomohide Hori from the Uehara Memorial Foundationpartial grant to Tomohide Hori from the Uehara Memorial Foundation

CD CRT-ⅡNIH R01NS051646-01A220094005 1Tokyo 171-0033Japan

2012

10.3748/wjg.v18.i22.2767

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.(22)
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