首页|Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk

Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk

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AIM:To examine the relationships between pre-diag-nostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS:A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplementation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007.Cases (n =50) were matched with two randomly selected controis (n =100).Conditional logistic regression models were used to investigate the associations between prediagnostic levels of hs-CRP,adiponectin,leptin,soluble vascular cell adhesion molecule-1 (sVCAM-1),soluble intercellular adhesion molecule-1,E-selectin,monocyte chemoattractant protein-1 and colorectal cancer risk.Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory poten tial of the models.RESULTS:Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend =0.03).Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend =0.02).No association was observed with any of the other biomarkers.Compared to standard models with known risk factors,those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement =0.01,RIDI =26.5％).CONCLUSION:These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk,respectively.These relationships must be confirmed in large validation studies.

Colorectal cancerAdiponectinSoluble vascular cell adhesion molecule-1Nested case-control study

Mathilde Touvier、Léopold Fezeu、Namanjeet Ahluwalia、Chantal Julia、Nathalie Charnaux、Angela Sutton、Caroline Méjean、Paule Latino-Martel、Serge Hercberg、Pilar Galan、Sébastien Czernichow

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INSERM U557(National Institute of Health and Medical Research), Inra, Cnam, University of Paris 13(UREN), SMBH, 74 rue Marcel Cachin, F-93017 Bobigny,France

Department of Biochemistry, Jean Verdicr Hospital, F-93140 Bondy, France

INSERM U698, University of Paris 13, F-93017 Bobigny, France

Department of Public Health, Avicenne Hospital(AP-HP), University of Paris 13, F-93017 Bobigny, France

Sébastien Czernichow, Department of Nutrition, Ambroise Paré Hospital(AP-HP), University of Versailles Saint Quentin,F-92100 Boulogne-Billancourt, France

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A grant from the French National Cancer Institute (Institut National du Cancer)

INCa 2007-1-SPC-3

2012

10.3748/wjg.v18.i22.2805

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.(22)
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