首页|Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma

Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma

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AIM:To investigate the intratumoral expression of metastasis-associated in colon cancer 1 (MACC1) and c-Met and determine their clinical values associated with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).METHODS:A retrospective study admitted three hundred fifty-four patients with HBV-related HCC.The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining.Prognostic factors influencing survival,metastasis and recurrence were assessed.RESULTS:Intratumoral MACC1 level was found to be associated with HCC disease progression.Both median tumor-free survival (TFS) and overall survival (OS) were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression,as compared to those with low intratumoral MACC1 levels (TFS:34 mo vs 48.0 mo,P ＜ 0.001; OS:40 mo vs 48 mo,P ＜ 0.01).Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome (P ＜ 0.001).CONCLUSION:High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC.MACC1 may serve as a prognostic biomarker for postoperative HCC.

Hepatocellular carcinomaMetastasis-associated in colon cancer 1c-MetPrognostic factorRecurrence

Jian-Hui Qu、Xiu-Juan Chang、Yin-Ying Lu、Wen-Lin Bai、Yan Chen、Lin Zhou、Zhen Zeng

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Center of Therapeutic Research for Liver Cancer, The 302nd Hospital, Beijing 100039, China

Key Scientific and Technological Research Foundation of the National Special-purpose ProgramCapital Medical Development and Research in Beijing,ChinaCapital Medical Development and Research in Beijing,China

2008ZX10002-0182007-10212009-2041

2012

10.3748/wjg.v18.i23.2995

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(23)
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