首页|Pseudomyxoma peritonei of 92 Chinese patients: Clinical characteristics, pathological classification and prognostic factors
Pseudomyxoma peritonei of 92 Chinese patients: Clinical characteristics, pathological classification and prognostic factors
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NETL
NSTL
万方数据
AIM:To assess the clinicopathologic features and its relationship with prognosis of pseudomyxoma peritonei (PMP) in Chinese patients.METHODS:The clinicopathologic features and follow-up data of 92 patients with PMP were reviewed and retrospectively analyzed.The cases were categorized into three groups:disseminated peritoneal adenomucinosis (DPAM),peritoneal mucinous carcinomatosis (PMCA),and peritoneal mucinous carcinomatosis with intermediate or discordant features (PMCA-I/D).The log-rank test was used to analyze survival for each group and various clinicopathological parameters.Multivariate Cox proportional-hazard models were constructed to determine the important factors associated with survival.RESULTS:The median age at diagnosis was 51.9 years (range:22-76 years).The median follow up was 124 mo.The 3-,5-and 10-year survival rates were 74.0％,67.4％ and 49.1％,respectively.There were 49 (53.2％)patients with DPAM,26 (28.3％) with PMCA-I and 17 (18.5％) with PMCA.Patients with DPAM,PMCA-I/D and PMCA exhibited statistically significant difference in survival (P =0.001).The 3 year survival for DPAM,PMCAI/D and PMCA was 97.0％,80.0％ and 67.0％,respectively; the 5 year survival was 80.0％,67.0％and 50.0％,respectively; and the 10 year survival was 65.0％,28.0％ and 14.0％,respectively.Survival rate was significantly lowest in patients ＜ 40 age years of age (P =0.011).Appendiceal tumor and extra-ovarian parenchymal organ involvement were significantly related to overall survival.Patients with appendiceal mucinous adenocarcinoma (MACA) showed the significantly poorer prognosis (P =0.011).Multivariate analysis showed that pathological classification,age,appendiceal tumor were significant related to overall survival.CONCLUSION:The clinical process "PMP" should be pathologically classified into DPAM,PMCA and PMCA-I/D.Pathological classification,age,appendiceal MACA are survival independent predictors in Chinese patients with PMR.
NETL
NSTL
万方数据
