首页|Relationship between HLA-DR gene polymorphisms and outcomes of hepatitis B viral infections: A meta-analysis
Relationship between HLA-DR gene polymorphisms and outcomes of hepatitis B viral infections: A meta-analysis
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AIM:To assess the rigorous relationship between human leukocyte antigens (HLA)-DR alleles and outcomes of hepatitis B virus (HBV) infections by means of metaanalysis.METHODS:Medline/PubMed,EMBASE,CNKI and VIP were searched to identify relevant studies.Study quality was evaluated using the Newcastle-Ottawa Scale.Odds ratios (OR) and 95％ confidence interval (95％CI) were pooled using Stata 11.0.Subgroup analyses were performed by ethnicity.Heterogeneity and publication bias analyses were performed to validate the credibility.RESULTS:A total of 2609 patients with chronic hepatitis B and 2606 controls spontaneously recovering from prior HBV infection were included.Meta-analysis showed that HLA-DR*04 (OR =0.72,95％ CI:0.60-0.85) and DR*13 (OR =0.27,95％ CI:0.19-0.37) alleles were significantly associated with HBV clearance while patients carrying HLA-DR*03 (OR =1.47,95％ CI:1.16-1.87)or DR*07 (OR =1.59,95％ CI:1.24-2.03) alleles had a significantly increased risk of chronic HBV persistence.For the HLA-DR*01 polymorphism,a significantly association with HBV clearance was found in Chinese Han group (OR =0.48,95％ CI:0.26-0.86),but not found in other ethnic groups (P =0.191).For other polymorphisms,no association with the HBV infection outcome was found.CONCLUSION:HLA-DR*04 and DR*13 alleles may be the protective factors for HBV clearance and HLADR*03,and DR*07 alleles may be the risk factors for HBV persistence.
Hepatitis B virusHuman leukocyte antigensMeta-analysisPolymorphism
Ze-Hui Yan、Yi Fan、Xiao-Hong Wang、Qing Mao、Guo-Hong Deng、Yu-Ming Wang
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Institute of Infectious Diseases, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China
国家自然科学基金国家重点基础研究发展规划(973计划)State Key Project Specialized for Infectious Diseases
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