首页|Gastroenterostoma after Billroth antrectomy as a premalignant condition

Gastroenterostoma after Billroth antrectomy as a premalignant condition

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Gastric stump carcinoma (GSC) following remote gastric surgery is widely recognized as a separate entity within the group of various types of gastric cancer.Gastrectomy is a well established risk factor for the development of GSC at a long time after the initial surgery.Both exoas well as endogenous factors appear to be involved in the etiopathogenesis of GSC,such as achlorhydria,hypergastrinemia and biliary reflux,Epstein-Barr virus and Helicobacter pylori infection,atrophic gastritis,and also some polymorphisms in interleukin-1β and maybe cyclo-oxygenase-2.This review summarizes the literature of GSC,with special reference to reliable early diagnostics.In particular,dysplasia can be considered as a dependable morphological marker.Therefore,close endoscopic surveillance with multiple biopsies of the gastroenterostomy is recommended.Screening starting at 15 years after the initial ulcer surgery can detect tumors at a curable stage.This approach can be of special interest in Eastern European countries,where surgery for benign gastroduodenal ulcers has remained a practice for a much longer time than in Western Europe,and therefore GSC is found with higher frequency.

Gastric stump cancerGastrectomyRisk factorsEndoscopic surveillance

Robert Sitarz、Ryszard Maciejewski、Wojciech P Polkowski、G Johan A Offerhaus

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Department of Pathology, University Medical Centre, Utrecht, 3584 CX Utrecht, The Netherlands

Department of Human Anatomy, Medical University of Lublin, 20-950 Lublin, Poland

Department of Surgical Oncology, Medical University of Lublin, 20-081 Lublin, Poland

Department of Surgical Oncology, Medical University of Lublin,U1.Staszica 11,20-081 Lublin, Poland

Department of Pathology, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands

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2012

10.3748/wjg.v18.i25.3201

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(25)
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