首页|Predictive value of 18F-fluorodeoxyglucose PET/CT for transarterial chemolipiodolization of hepatocellular carcinoma

Predictive value of 18F-fluorodeoxyglucose PET/CT for transarterial chemolipiodolization of hepatocellular carcinoma

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AIM:To investigate the correlation of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) with clinical features and the prediction of treatment response.METHODS:A total of 83 hepatocellular carcinoma (HCC) patients undergoing 18F-FDG PET before transarterial chemolipiodolization with systemic chemo-infusion between October,2006 and May,2009 were retrospectively enrolled.The patients included 68 men and 15women (mean age,60 ± 10.7 years).The effect of 18F-FDG-monitored PET uptake on clinical features and on the evaluated treatment response was ascertained with modified Response Evaluation Criteria in Solid Tumors.The PET parameters of maximal standardized uptake value of the tumor (TSUVmax),the ratio of the tumor maximal standardized uptake value (SUV) to the liver maximal SUV (TSuVmax/LSuVmax) and the ratio of tumor maximal SUV to the liver mean SUV (TSuVmax/LSuVmean)were tested as predictive factors.RESULTS:Among the 3 SUV parameters,the Tsuvmax/lsuVmean ratio (cutoff value of 1.90) was significantly associated with tumor burden including tumor size,tumor number,α-fetoprotein levels and tumor stage (P ＜0.001,P =0.008,P =0.011,P ＜ 0.001,respectively).The objective response rates in patients with a high SUV ratio (≥ 1.90) were significantly better than those with a low SUV ratio (＜ 1.90) (P =0.020).The overall survival rates of patients exhibiting a low Tsuwax/LSu-Vmean ratio (＜ 1.90) and those with a high SUV ratio (≥1.90) was 38.2 and 10.3 mo,respectively (P ＜ 0.01).However,the time to progression showed no significant difference between the groups (P =0.15).CONCLUSION:18F-FDG PET can be an important predictor of HCC treatment.In particular,the Tsuvmax/LsUVmean ratio (cutoff value of 1.90) can provide useful information in treatment prognosis for HCC patients treated with locoregional therapy.

18F-fluorodeoxyglucose positron emission tomographyTransarterial chemolipiodolization with systemic chemo-infusionTreatment responsePredictive factorOverall survival

Myeong Jun Song、Si Hyun Bae、Ie Ryung Yoo、Chung-Hwa Park、Jeong Won Jang、Ho Jong Chun、Byung Gil Choi

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Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea

Department of Nuclear, Medicine College of Medicine, The Catholic University of Korea, Seoul 137-040,South Korea

Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea

National R and D Program grant for cancer control,Ministry of Health,Welfare and Family Affairs,South Korea

R0620390-1

2012

10.3748/wjg.v18.i25.3215

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(25)
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