首页|Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis
Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis
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原文链接
NETL
NSTL
万方数据
维普
AIM:TO determine if the fraction of Nardostachysjatamansi (NJ) has the potential to ameliorate the severity of acute pancreatitis (AP).METHODS:Mice were administered the biologically active fraction of NJ,i.e.,the 4th fraction (NJ4),intraperitoneally,and then injected with the stable cholecystokinin analogue cerulein hourly for 6 h.Six hours after the last cerulein injection,the pancreas,lung,and blood were harvested for morphological examination,measurement of cytokine expression,and examination of neutrophil infiltration.RESULTS:NJ4 administration attenuated the severity of AP and lung injury associated with AP.It also reduced cytokine production and neutrophil infiltration and resulted in the in vivo up-regulation of heme oxygenase-1 (HO-1).Furthermore,NJ4 and its biologically active fraction,N J4-2 inhibited the cerulein-induced death of acinar cells by inducing HO-1 in isolated pancreatic acinar cells.CONCLUSION:These results suggest that NJ4 may be a candidate fraction offering protection in AP and NJ4 might ameliorate the severity of pancreatitis by inducing HO-1 expression.
NETL
NSTL
万方数据
维普
