首页|Increased frequency and clinical significance of myeloidderived suppressor cells in human colorectal carcinoma

Increased frequency and clinical significance of myeloidderived suppressor cells in human colorectal carcinoma

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AIM:To investigate the frequency and clinical significance of the myeloid-derived suppressor cells (MDSC) in human colorectal carcinoma (CRC).METHODS:Samples of peripheral blood and tumor tissue from 49 CRC patients were analyzed.Mononuclear cells were isolated by Ficoll-Hypaque density gradient centrifugation and were subjected to a flow cytometrybased immunophenotypic analysis.RESULTS:A considerable increase in the percentage of CD33+HLA-DR MDSCs was observed in the peripheral blood (1.89％ ± 0.75％) and tumor tissues (2.99％± 1.29％) of CRC patients as compared with that in the peripheral blood of healthy controls (0.54％ ± 0.35％).This expanded CD33+HLA-DR-subset exhibited immature myeloid cell markers,but not lineage markers,and showed up-regulation of CD18/CD11b expression as compared with the MDSCs from healthy donors.Further studies showed that the MDSC proportion in CRC peripheral blood was correlated with nodal metastasis (P =0.023),whereas that in tumor tissues was correlated with nodal/distant metastasis (P =0.016/P =0.047) and tumor stage (P =0.028),suggesting the involvement of MDSCs in CRC tumor development.CONCLUSION:Characterization of MDSCs in CRC suggests the clinical significance of circulating and tumorinfiltrating MDSCs and may provide new insights into the CRC immunotherapy targeting MDSCs.

Myeloid-derived suppressor cellColorectal carcinomaTumor metastasis

Hong-Li Sun、Xin Zhou、Yi-Feng Xue、Ke Wang、Yun-Feng Shen、Jing-Jue Mao、Hong-Feng Guo

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Department of Hematology, Wuxi People's Hospital, Wuxi 214023, Jiangsu Province, China

Department of Clinical Laboratory, Wuxi People's Hospital, Wuxi 214023, Jiangsu Province, China

Department of General Surgery, Wuxi Third People's Hospital, Wuxi 214023, Jiangsu Province, China

2012

10.3748/wjg.v18.i25.3303

世界胃肠病学杂志(英文版)
太原消化病研治中心

世界胃肠病学杂志(英文版)

SCI
影响因子：1.001
ISSN：1007-9327
年,卷(期)：2012.18(25)
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